̽»¨¾«Ñ¡

Physical modelling of biological systems, Complex systems, Active matter, Biophysics

Signalling systems, toxins, structural biology, peptide activity, plant pathogen interactions.

Advanced light microscopy, cell migration, tissue dynamics, biomechanics, active matter physics, developmental biology, tissue regeneration

Bridging Active Matter Physics with Gene Regulation and Biological Evolution

evidence synthesis, comparative effectiveness research, networks of studies, complex interventions, sparse data, automation tools, knowledge translation

Development of new methods and software that will allow a) integrating data from diverse sources to reduce waste in research, b) taking into account societal and environmental factors in healthcare, c) promoting accessibility, transparency and open science.

microbial proteins, solar foods, CO2 capture and utilization, green hydrogen production, bio-hybrid energy conversion systems

CO2-containing industrial waste gasses and green hydrogen from water photoelectrolysis are converted to proteins through bioengineered microbial cultures with no additional lands needs. To achieve this goal a socially placed bio-hybrid energy conversion system is proposed. The following disciplines must be converged to ensure the applicability of this groundbreaking system/approach: electrochemistry, semiconductors physics, biochemistry and biotechnology, engineering and social sciences.

cellular dormancy, suspended animation, neuroprotection, longevity, gene regulation, C. elegans

Cancer immunotherapy, immunology, macrophages, T cells, tumor on chip, cell biology

Development of novel strategies for cancer immunotherapy. T cell-based immunotherapies have revolutionized cancer treatment, but most patients with advanced cancer do not respond to current treatments or relapse. We propose to develop alternative strategies for cancer immunotherapy by taking advantage of other types of immune cells with anti-cancer activity such as macrophages. The ability of macrophages to eliminate invading bacteria may potentially be used to fight cancer, and vice versa.

Brain lipids, Synapse, Nutrition, Cognitive health

mechanobiology, cellular and tissue motion, mechanics and dynamics, morphogenesis, sports physiology and biomechanics, novel imaging methods, traditional and AI-based image analysis, biosensor data collection and modeling.

Alexander Eiler

Antibiotic resistance, Microbiology, Food webs, Marine biodiversity, Microplastics

Microplastic toxicology, Fish gut microbiome, Bioaccumulation of antibiotic resistance

disease models, drug discovery, drug and environmental toxicology, rare diseases

in vivo exposome biology - identifying molecular triggers and pathways that trigger disease and progression

Lifespan; Brain development and aging; Aging; Brain disease

Determinant of brain health and cognition - societal, genetic and behavioral moderators

Forensic Genetics, RNA markers for body fluid identification and time since deposition analysis, microbial signatures for forensic applications, Forensic Activity Level Assessments

Forensic Microbiome Analysis. This project explores microbiome-based forensic applications, focusing on geolocalization from soil, body fluid identification, and linking traces to donors.

Genetics of rare congenital brain diseases Molecular disease mechanisms

Philosophy of medicine; Philosophy of science in practice.

Knowledge gaps and epistemic injustice in medical research.

Osman Gani

Computer-aided drug design (CADD). Molecular Modeling

Immunology

Gunnveig Grødeland

Pandemics, viruses, vaccines

Modeling of viral spread by digital twins, factoring in vaccine efficay

Liver/biliary disease. Microbiome. Metabolomics. Gnotobiotic mouse models. Clinical biomarkers. Clinical trials.

Marit Inngjerdingen

Extracellular vesicles, immunology, intestinal organoids, pharmacology, nanotherapy

comparative genomics, biodiversity genomics, cell and molecular biology, environmental biology

A One Health perspective on the ecological crisis in the ̽»¨¾«Ñ¡fjord - a transdisciplinary collaboration between OUS/Medical Faculty and MN Faculty in LVB

vertebrate immunology, aquaculture

Comparative studies of immune responses in mammals, fish and fish with evoutionary losses of immune genes important for function of the mammalian adaptive immune system (e.g. MHC class II locus lost in Atlantic cod). An emphasis on evolution of antibody responses in vaccinated (or infected) induviduals (i.e. days and weeks) as well as in evolutionary time (million years), by comparison between species.

Emma LÃ¥ng

Main interests: wound healing, cancer progression, tissue development, and inflammatory skin disorders. Main expertise: Cell- and molecular biology, advanced light microscopy, and computer-based image analyses.

We combine experimental cell biology, mathematical modeling, and physical theory to explore cellular dynamics and uncover mechanisms that can improve health and treatment regimens. With expertise in advanced light microscopy - including live cell imaging, high-content imaging, and multiplex imaging - we aim to understand cellular mechanisms to determine the best ways to manipulate or stimulate impaired processes in disease contexts, ultimately enhancing therapeutic outcomes. Our work bridges basic science with clinical applications, addressing challenges in health and disease.

microbial proteins, solar foods, CO2 capture and utilization, green hydrogen production, bio-hybrid energy conversion systems

Child development, Translational research, Brain development, Autism spectrum disorders, Language, Social function, Genetics, immunology, Etichs in biological research.

Normal and abnormal development. Our K.G. Jebsen centre on neurodevelopmental disorders have access to substantial amount of clinical and biological data on normal and abnormal development from infancy to adult. The centre is already highly interdisiplanary but a convergence cente could add more emphasis on research in language, history, social aspects and ethics.

I am a sociologist of science with expertise in how to best create the kinds of organizations, groups, and social interactions that best facilitate creative interdisciplinary research. My interest is in joining a team to help them plan how they might best organize themselves for interdisciplinary success.

Intracellular traffic, organelle homeostasis, cell migration, mechanobiology

Precision Health, Science and Society

With the growth of misinformation, there is growing mistrust in science. I would like to integrate data from social media with metrics from scientific publications to investigate the interactions between science and society. For example, which scientific publications generate the most interest on social media? Which ones are associated with positive discussions?which ones are most misrepresented.?This would be a good opportunity for collaborations involving clinicians, life scientist and social sciences

Radiotherapy, Radiation protection, Radiobiology, Accelerator physics

* Sarcopenia / skeletal muscle aging * Environmental pollutants and their impacts on metabolic diseases * Cancer cachexia We perform basic research studies (molecular biology)

No concrete project idea right now, but should be on thematic related to * Sarcopenia / skeletal muscle aging * Environmental pollutants and their impacts on metabolic diseases * Cancer cachexia

Bioanalytical Chemistry; Liquid chromatography-mass spectrometry; automated sample preparation; Health effects of persistent organic pollution; PFAS; Exposome; Metabolomics

Rare diseases, Genetics, primary immune deficiencies, inborn errors of immunity, neuroimmunology

From variant to function. Improving understanding of how human coding and non-coding variants contribute to molecular, cellular and organismal phenotypes, particularly in immune system.

Molecular and cell biology of stress signaling, Cancer biology - mechanisms, identification of biomarkers and novel therapies, Physiological and molecular/cell biological effects of mind/body practices

Cancer epigenetics, gene expression control, enhancer malfunction and epigenome reprogramming by transcription factors, next-generation sequencing and single cell multomics

Understand the role of non-genetic mechanisms such as enhancer and epigenome reprogramming in cancer initiation, progression, metastasis and treatment resistance. Using high resolution enhancer landscapes in accessible chromatin and gene expression data from single cell analysis.

Global health, AI, climate resilience, early warning

Several ideas at this stage, including "Early warning and decision support for cost-effective reponse to climate-influenced health impacts". Using machine learning/AI to learn how to forecast climate-sensitive disease incidence as part of early warning and response systems, perhaps including a focus on cost effectiveness as part of decision support. Also include socio-technical aspects.

Membrane dynamics, vesicle trafficking, macropinocytosis, cell migration, cancer cell biology, advanced microscopy

Biodiversity, ecology, biogeography, spatial modelling, ecological climatology, population biology, experimental ecology, urban ecology, conservation biology, invasive species

Statistical ecology; biodiversity monitoring and management

Transplantation, organ preservation, heart, liver, ischemia reperfusion, organ perfusion, ethics, dissemination

Preserve organs for transplantation, test viability of organs on perfusion machines, discuss ethical/juridical aspects of organ donation.

Cancer drug discovery, Drug resistance, Game theory, Data analysis

Understanding of immune-healthy-cancer dynamics on 3D spheroids.

Precision nutrition; Machine learning for small data; Data integration; Biomarker discovery; Statistical variable selection

Climate health, antibiotic utilization, research reproducibility

Precision nutrition, omics technologies, dietary interventions

I am part of Magne Thoresen's project idea regarding Precision nutrition

Dag Undlien

Genomic medicine

Physical modelling of biological systems, Complex systems, Active matter, Biophysics

Stem cells, stem cell niches, cancer, development

The project focusses on women fertility from various innovative angles.

microbial proteins, solar foods, CO2 capture and utilization, green hydrogen production, bio-hybrid energy conversion systems

CO2-containing industrial waste gasses and green hydrogen from water photoelectrolysis are converted to proteins through bioengineered microbial cultures with no additional lands needs. To achieve this goal a socially placed bio-hybrid energy conversion system is proposed. The following disciplines must be converged to ensure the applicability of this groundbreaking system/approach: electrochemistry, semiconductors physics, biochemistry and biotechnology, engineering and social sciences.

cellular dormancy, suspended animation, neuroprotection, longevity, gene regulation, C. elegans

Cancer immunotherapy, immunology, macrophages, T cells, tumor on chip, cell biology

Development of novel strategies for cancer immunotherapy. T cell-based immunotherapies have revolutionized cancer treatment, but most patients with advanced cancer do not respond to current treatments or relapse. We propose to develop alternative strategies for cancer immunotherapy by taking advantage of other types of immune cells with anti-cancer activity such as macrophages. The ability of macrophages to eliminate invading bacteria may potentially be used to fight cancer, and vice versa.

Ageing, Machine learning, AI, multi omics, longitudinal data

Healthy ageing – Prevention is better than cure. Using clinical data and biomaterial we want to define signatures in the general population that characterises ageing driven DNA damage.

disease models, drug discovery, drug and environmental toxicology, rare diseases

in vivo exposome biology - identifying molecular triggers and pathways that trigger disease and progression

Lifespan; Brain development and aging; Aging; Brain disease

Determinant of brain health and cognition - societal, genetic and behavioral moderators

Osman Gani

Computer-aided drug design (CADD). Molecular Modeling

Liver/biliary disease. Microbiome. Metabolomics. Gnotobiotic mouse models. Clinical biomarkers. Clinical trials.

Rene Huster

Cognition, Cognitive electrophysiology, MR imaging, Sleep

Open schooling collaboration, transformative change, ̽»¨¾«Ñ¡fjorden environmental crisis, knowledge co-creation and adaptation for action

Life science, education and arts for transformative change (LifeArts) aims to create and investigate the conditions and resources necessary for bridging the gaps between knowledge and transformative action towards sustainability through interdisciplinary, inter-sectoral social innovation. LifeArts will build on existing partnerships exploring the use of expressions of art and art processes to explore future thinking, narratives of change, and humans ability to make sense. Shapes of knowledge will be analyzed as representational means across time and settings as traces of learning and emergent knowledge and new practices. The open schooling collaboration is built around the urgent need to address the environmental crises in the ̽»¨¾«Ñ¡fjord.

quality of life in dentistry, tooth loss, biomaterials, periodontology

Ageing, Machine learnring, AI, Multi-omics data, Longitudinal, Age-related diseases

Age is the primary cause and risk factor for the majority of diseases, slowing down aging has huge personal and societal benefits by minimizing the disease burden that comes with aging process. We aim to develop a framework for personalised healthy aging interventions using machine-learrning to intergrate longitudinal clinical data and multiomic data.

microbial proteins, solar foods, CO2 capture and utilization, green hydrogen production, bio-hybrid energy conversion systems

Real-World Data, Pharmacoepidemiology, Pharmacology, Women's health, Pregnancy, Neurosciences

Norway is home to some of the world's most comprehensive and well-maintained health care registries. These registries contain valuable data on patient demographics, diagnoses, treatments, and outcomes, and represent a tremendous opportunity for researchers to gain insight into the effectiveness and safety of pharmaceuticals for patients in real-world settings. A convergence environment would have the potential to improving accessibility, interoperability and efficiency of Norwegian health care data for health research, education and innovation.

I am a sociologist of science with expertise in how to best create the kinds of organizations, groups, and social interactions that best facilitate creative interdisciplinary research. My interest is in joining a team to help them plan how they might best organize themselves for interdisciplinary success.

Radiotherapy, Radiation protection, Radiobiology, Accelerator physics

* Sarcopenia / skeletal muscle aging * Environmental pollutants and their impacts on metabolic diseases * Cancer cachexia We perform basic research studies (molecular biology)

No concrete project idea right now, but should be on thematic related to * Sarcopenia / skeletal muscle aging * Environmental pollutants and their impacts on metabolic diseases * Cancer cachexia

Rare diseases, Genetics, primary immune deficiencies, inborn errors of immunity, neuroimmunology

From variant to function. Improving understanding of how human coding and non-coding variants contribute to molecular, cellular and organismal phenotypes, particularly in immune system.

Molecular and cell biology of stress signaling, Cancer biology - mechanisms, identification of biomarkers and novel therapies, Physiological and molecular/cell biological effects of mind/body practices

Membrane dynamics, vesicle trafficking, macropinocytosis, cell migration, cancer cell biology, advanced microscopy

1. Innovative treatment of patients who lose their sense of smell and/or taste due to different causes. 2. Innovative treatment of patients with oral burning sensation. 3. Understanding how brain processes smell, taste and oral pain.

Molecular microbiology, antimicrobial resistance, vaccine development, One health, animal health.

Antimicrobial resistance is one of the major global health threats. Our research groups is interested in approaching this problem on different ways from to understand basic biological mechanisms to drug use and new antimicrobial strategies.

Brain health, diet, omega 3 fatty acids

Age-related cognitive decline and neurodevelopmental disorders pose significant challenges to global health, emphasizing the need to understand dietary influences on brain function. We want to investigate neurobiological mechanisms by which dietary omega-3 fatty acids influence synaptic growth, plasticity, and cognitive function. Building on preliminary findings showing omega-3’s positive effects on synaptic glutamate receptor expression and spatial memory, we aim to explore the translational potential of omega-3 intake in neuroprotection and cognitive health across the lifespan.

toxicology, environmental pollution, environmental health, occupational health Africa agriculture, agrochemicals, pesticides

Neuroscience, Memory

Attention is important for memory. How is attention formed in the brain and how is it used to successfully form memories? My idea is to record neural data in humans while they perform a memory task that is highly dependent on attention.